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NeoTYPE® Thyroid Profile
- Next Generation Sequencing (NGS)
The NeoTYPE Thyroid Tumor Profile analyzes 32 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (26 genes + 2 biomarkers): AKT1, ALK, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, HRAS, KRAS, MEN1, MET, Microsatellite Instability (MSI), NF1, NF2, NRAS, PIK3CA, PTEN, RET, SMAD4, SMO, SRC, TERT Promoter, TP53, TSC1, TSC2, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, RET (tech-only available) IHC (2 biomarkers): PD-L1 LDT, Pan-TRK (tech-only available for PD-L1).
Specimen Requirements
FFPE tissue: Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.
Storage and Transportation
Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81457x1, 88377x2, 88360x1, 88342x1; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| HRAS | KRAS | NRAS | ALK | MEN1 | NF1 |
| NF2 | RET | CDKN2A | TERT | AKT1 | ARID1A |
| ATM | CTNNB1 | ERBB2 | ERBB4 | MET | TSC1 |
| TSC2 | SMO | PIK3CA | PTEN | SMAD4 | TP53 |
| SRC | BRAF | ||||
| Genomic Signatures | |||||
|---|---|---|---|---|---|
| MSI | TMB | ||||
Immunohistochemistry (IHC)
| Expression | |||||
|---|---|---|---|---|---|
| PD-L1 | NTRK1 | NTRK2 | NTRK3 | ||
Fluorescence In Situ Hybridization (FISH)
| Amplification(s) | |||||
|---|---|---|---|---|---|
| MET | |||||
| Structural Rearrangement(s) | |||||
|---|---|---|---|---|---|
| RET | |||||
Last Updated: December 06, 2025