NeoTYPE® Pancreas Tumor Profile

The NeoTYPE Pancreas Tumor Profile analyzes 69 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. If global HER2 (Other) IHC w/Breast Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/Breast Scoring unless reflex to tech-only FISH or reflex opt-out is requested. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (63 genes + 2 biomarkers): ACVR1B, ARID1A, ATM, ATR, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CDK12, CDKN2A, CDKN2B, CHEK1, CHEK2, EGFR, ERBB2, ERBB4, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FGFR1, FGFR2, FGFR3, FGFR4, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MEN1, MET, Microsatellite Instability (MSI), MLH1, MRE11A (MRE11), MSH2, MSH6, , NBN, NF1, NOTCH1, NRAS, PALB2, PBRM1, PIK3CA, PMS2, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, RNF43, SMAD4, SMO, STK11, TGFBR2, TERT Promoter, TP53, Tumor Mutation Burden (TMB), VHL FISH (2 FISH): MET, PTEN (tech-only available) IHC (3 biomarkers): HER2 (Other) IHC w/Breast Scoring, PD-L1 LDT, Pan-TRK (tech-only available for HER2 and PD-L1).