NEO PanTracer Pro

Next Generation Sequencing (NGS)

The pan-solid tumor assay is designed to guide therapy selection and identify clinical trial options for patients with advanced stage solid tumors. It detects genomic alterations that are most relevant to diagnosis, therapy selection, prognosis, and clinical trial options in solid tumors.

The addition of IHC and ancillary testing provides comprehensive information for therapy selection beyond standard CGP testing. It is ideal for patients with newly diagnosed, recurrent, or progressive advanced cancer with an unusual clinical presentation who need thorough coverage for clinical investigation.

Diagnosis information you provide will determine tumor type-directed IHC and ancillary testing. See PanTracer Pro Testing by Cancer Type for the full list of associated add-ons by cancer diagnosis.

Turnaround time

8-10 Days

CGP: 8-10 Days
IHC: 2 Days
ISH: 5 Days
LBx Reflex: 7 Days

Level of Service

Global

New York Approved: Yes

Specimen Requirements

Paraffin blocks (preferred):
FFPE block surface area: Minimum 25 mm2/section ≥ 5 mm2 of tissue surface area and ≥20% tumor (~500 tumor cells); ≥40% tumor required for HRD assessment. Use a single block for large resections where tumor is abundant, or up to 4 blocks from procedures with smaller specimens (eg, core biopsy, cell block). Only blocks from the same procedure and the same tumor should be submitted together.
Unstained slides: Large resection specimens
25 unstained slides at 4-5-micron thickness which includes unstained slides for H&E. Please use positively charged slides and 10% NBF fixative. Do not use zinc fixative. Decalcified samples are not accepted.
Unstained slides: Cell blocks/FNAs and small needle core biopsies
25 unstained slides which includes unstained slides for H&E. Please use positively charged slides and 10% NBF fixative. Do not use zinc fixative. Decalcified samples are not accepted.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*

81459x1 for NGS 88342 x 1 or 88341 x 1; 88361 x 1; 88360 x 1 can be added for each IHC

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

SNVs + Indels
ABL1	ABL2	ABRAXAS1	ACVR1	ACVR1B	ADGRA2
AKT1	AKT3	ALOX12B	AMER1	ANKRD11	ANKRD26
APC	ARAF	ARFRP1	ARID1A	ARID1B	ARID2
ARID5B	ASXL1	ASXL2	ATR	ATRX	AURKA
AURKB	AXIN1	AXIN2	AXL	B2M	BAP1
BARD1	BBC3	BCL10	BCL2	BCL2L1	BCL2L11
BCL2L2	BCL6	BCOR	BCORL1	BCR	BIRC3
BLM	BMPR1A	BRD4	BRIP1	BTG1	BTK
CALR	CARD11	CASP8	CBFB	CBL	CCN6
CCND2	CD274	CD276	CD74	CD79A	CD79B
CDC73	CDH1	CDK12	CDKN1A	CDKN1B	CDKN2A
CDKN2B	CDKN2C	CEBPA	CENPA	CHD2	CHD4
CIC	COP1	CREBBP	CRKL	CRLF2	CSF1R
CSF3R	CSNK1A1	CTCF	CTLA4	CTNNA1	CTNNB1
CUL3	CUX1	CXCR4	CYLD	DAXX	DCUN1D1
DDR2	DDX41	DHX15	DICER1	DIS3	DNAJB1
DNMT1	DNMT3A	DNMT3B	DOT1L	E2F3	EED
EGFL7	EIF1AX	EIF4A2	EIF4E	ELOC	EML4
EMSY	EP300	EPCAM	EPHA3	EPHA5	EPHA7
EPHB1	ERBB4	ERCC3	ERCC4	ERCC5	ERG
ERRFI1	ETS1	ETV1	ETV4	ETV5	ETV6
EWSR1	EZH2	FANCA	FANCC	FANCD2	FANCE
FANCF	FANCG	FANCI	FANCL	FAS	FAT1
FBXW7	FH	FLCN	FLI1	FLT1	FLT3
FLT4	FOXA1	FOXL2	FOXO1	FOXP1	FRS2
FUBP1	FYN	GABRA6	GATA1	GATA2	GATA3
GATA4	GATA6	GEN1	GID4	GLI1	GNA11
GNA13	GNAQ	GNAS	GPS2	GREM1	GRIN2A
GRM3	GSK3B	H1-2	H2BC5	H3-3A	H3-3B
H3-4	H3-5	H3C1	H3C10	H3C11	H3C12
H3C13	H3C14	H3C15	H3C2	H3C3	H3C4
H3C6	H3C7	H3C8	HGF	HNF1A	HNRNPK
HOXB13	HRAS	HSD3B1	HSP90AA1	ICOSLG	ID3
IDH1	IDH2	IFNGR1	IGF1	IGF1R	IGF2
IKBKE	IKZF1	IL10	IL7R	INHA	INHBA
INPP4A	INPP4B	INSR	IRF2	IRF4	IRS1
IRS2	JAK1	JAK3	JUN	KAT6A	KDM5A
KDM5C	KDM6A	KDR	KEAP1	KEL	KIF5B
KLF4	KLHL6	KMT2A	KMT2AT3	LATS1	LATS2
LMO1	LRP1B	LYN	LZTR1	MAGI2	MALT1
MAP2K1	MAP2K2	MAP2K4	MAP3K1	MAP3K13	MAP3K14
MAP3K4	MAPK1	MAPK3	MAX	MCL1	MDC1
MED12	MEF2B	MEN1	MGA	MITF	MLH1
MPL	MRE11	MSH2	MSH3	MSH6	MST1
MST1R	MTOR	MUTYH	MYB	MYD88	MYOD1
NAB2	NBN	NCOA3	NCOR1	NEGR1	NF1
NF2	NFE2L2	NFKBIA	NKX2-1	NKX3-1	NOTCH1
NOTCH2	NOTCH3	NOTCH4	NPM1	NSD1	NTRK1
NTRK2	NTRK3	NUP93	NUTM1	PAK1	PAK3
PAK5	PALB2	PARP1	PAX3	PAX5	PAX7
PAX8	PBRM1	PDCD1	PDCD1LG2	PDGFRA	PDPK1
PGR	PHF6	PHOX2B	PIK3C2B	PIK3C2G	PIK3C3
PIK3CD	PIK3CG	PIK3R1	PIK3R2	PIK3R3	PIM1
PLCG2	PLK2	PMAIP1	PMS1	PMS2	PNRC1
POLD1	POLE	PPARG	PPM1D	PPP2R1A	PPP2R2A
PPP6C	PRDM1	PREX2	PRKAR1A	PRKCI	PRKDC
PRKN	PRSS8	PTCH1	PTPN11	PTPRD	PTPRS
PTPRT	QKI	RAB35	RAC1	RAD21	RAD50
RAD51	RAD51B	RAD51C	RAD51D	RAD52	RAD54L
RANBP2	RARA	RASA1	RB1	RBM10	RECQL4
REL	RHEB	RHOA	RIT1	RNF43	ROS1
RPS6KA4	RPS6KB2	RPTOR	RUNX1	RUNX1T1	RYBP
SDHA	SDHAF2	SDHB	SDHC	SDHD	SETBP1
SETD2	SF3B1	SH2B3	SH2D1A	SHQ1	SLIT2
SLX4	SMAD2	SMAD3	SMAD4	SMARCA4	SMARCB1
SMARCD1	SMC1A	SMC3	SMO	SNCAIP	SOCS1
SOX10	SOX17	SOX2	SOX9	SPEN	SPOP
SPTA1	SRC	SRSF2	STAG1	STAG2	STAT3
STAT4	STAT5A	STAT5B	STK11	STK40	SUFU
SUZ12	SYK	TAF1	TBX3	TCF3	TCF7L2
TENT5C	TERC	TERT	TET1	TET2	TFE3
TGFBR1	TGFBR2	TMEM127	TMPRSS2	TNFAIP3	TNFRSF14
TOP1	TOP2A	TP53	TP63	TRAF2	TRAF7
TSC1	TSC2	TSHR	U2AF1	VEGFA	VHL
VTCN1	WT1	XIAP	XPO1	XRCC2	YAP1
YES1	ZBTB2	ZBTB7A	ZFHX3	ZNF217	ZNF703
ZRSR2

CNVs
AKT2	ALK	AR	ATM	BRAF	BRCA1
BRCA2	CCND1	CCND3	CCNE1	CDK4	CDK6
CDK8	CHEK1	CHEK2	EGFR	ERBB2	ERBB3
ERCC1	ERCC2	ESR1	FGF1	FGF10	FGF14
FGF19	FGF2	FGF23	FGF3	FGF4	FGF5
FGF6	FGF7	FGF8	FGF9	FGFR1	FGFR2
FGFR3	FGFR4	JAK2	KIT	KRAS	LAMP1
MDM2	MDM4	MET	MYC	MYCL1	MYCN
NRAS	NRG1	PDGFRA	PDGFRB	PIK3CA	PIK3CB
PTEN	RAF1	RET	RICTOR	RPS6KB1	TFRC

Genomic Signatures
HRD	MSI	TMB

RNA Sequencing

Fusions
ABL1	AKT3	ALK	AXL	BRAF	BRCA1
BRCA2	CDK4	CSF1R	EML4	ERBB2	ERG
ESR1	ETS1	ETV1	ETV4	ETV5	ETV6
EWSR1	FGFR1	FGFR2	FGFR3	FGFR4	FLI1
FLT1	FLT3	JAK2	KDR	KIF5B	KIT
KMT2A	KMT2AT3	MSH2	MYC	NOTCH1	NOTCH2
NOTCH3	NRG1	NTRK1	NTRK2	NTRK3	PAX3
PAX7	PDGFRA	PDGFRB	PIK3CA	PPARG	RAF1
RET	ROS1	RPS6KB1	TMPRSS2

Splice Variant
AR	AR-V7
EGFR	EGFRvIII
MET	MET exon 14 Skipping

Immunohistochemistry (IHC)

Expression
ALK	AR	c-MET	Claudin-18	ER	FOLR1
HER2	KI67	PD-L1	PGR	PTEN	ROS1
TP53

Last Updated: March 02, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.