NEO PanTracer Pro

Next Generation Sequencing (NGS)

The pan-solid tumor assay is designed to guide therapy selection and identify clinical trial options for patients with advanced stage solid tumors. It detects genomic alterations that are most relevant to diagnosis, therapy selection, prognosis, and clinical trial options in solid tumors.

The addition of IHC and ancillary testing provides comprehensive information for therapy selection beyond standard CGP testing. It is ideal for patients with newly diagnosed, recurrent, or progressive advanced cancer with an unusual clinical presentation who need thorough coverage for clinical investigation.

Diagnosis information you provide will determine tumor type-directed IHC and ancillary testing. See PanTracer Pro Testing by Cancer Type for the full list of associated add-ons by cancer diagnosis.

Turnaround time

8-10 Days

CGP: 8-10 Days
IHC: 2 Days
ISH: 5 Days
LBx Reflex: 7 Days

Level of Service

Global

New York Approved: Yes

Specimen Requirements

Paraffin blocks (preferred):
FFPE block surface area: Minimum 25 mm2/section ≥ 5 mm2 of tissue surface area and ≥20% tumor (~500 tumor cells); ≥40% tumor required for HRD assessment. Use a single block for large resections where tumor is abundant, or up to 4 blocks from procedures with smaller specimens (eg, core biopsy, cell block). Only blocks from the same procedure and the same tumor should be submitted together.
Unstained slides: Large resection specimens
25 unstained slides at 4-5-micron thickness which includes unstained slides for H&E. Please use positively charged slides and 10% NBF fixative. Do not use zinc fixative. Decalcified samples are not accepted.
Unstained slides: Cell blocks/FNAs and small needle core biopsies
25 unstained slides which includes unstained slides for H&E. Please use positively charged slides and 10% NBF fixative. Do not use zinc fixative. Decalcified samples are not accepted.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

CPT Code(s)*

81459x1 for NGS 88342 x 1 or 88341 x 1; 88361 x 1; 88360 x 1 can be added for each IHC

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

SNVs + Indels
KMT2AT3	ABL1	ABL2	CDKN2A	CRLF2	CSF1R
FLT3	IKZF1	IL7R	JAK1	JAK3	NTRK1
NTRK2	NTRK3	PDGFRA	SH2B3	TP53	ASXL1
BCOR	CEBPA	CSF3R	DNMT3A	ETV6	EZH2
HRAS	IDH1	IDH2	KMT2A	NPM1	PHF6
PTPN11	RUNX1	SETBP1	SF3B1	SRSF2	STAG2
TET2	U2AF1	WT1	ZRSR2	BRIP1	DDX41
ERCC4	PALB2	RAD51C	SLX4	TERC	TERT
XRCC2	AKT1	ARID1A	ATR	BARD1	CDH1
CDK12	CTNNB1	ERBB4	FANCA	FANCC	FANCD2
FANCE	FANCF	FANCG	FANCL	GATA3	MLH1
MRE11	MSH2	MSH6	NBN	PMS2	RAD50
RAD51	RAD51B	RAD51D	RAD54L	SMAD4	SMO
SRC	APC	BAP1	PBRM1	BCL2	BIRC3
BTK	CARD11	CD79B	MYD88	NOTCH1	CXCR4
EPCAM	FBXW7	PLCG2	MUTYH	POLD1	POLE
RNF43	STK11	ATRX	ACVR1B	AKT3	AMER1
ARAF	ARFRP1	ARID1B	ARID2	AURKA	AURKB
AXIN1	AXL	BCL2L1	BCL2L2	BCL6	BCORL1
BLM	BRD4	BTG1	EMSY	CBFB	CBL
CCND2	CD274	CD79A	CDC73	CDKN1A	CDKN1B
CDKN2B	CDKN2C	CHD2	CHD4	CIC	CREBBP
CRKL	CTCF	CTNNA1	CUL3	CYLD	DAXX
DDR2	DICER1	DOT1L	EP300	EPHA3	EPHA5
EPHA7	EPHB1	ERG	ERRFI1	TENT5C	FAS
FAT1	FH	FLCN	FLT1	FLT4	FOXL2
FOXP1	FRS2	FUBP1	GABRA6	GATA1	GATA2
GATA4	GATA6	GID4	GLI1	GNA11	GNA13
GNAQ	GNAS	ADGRA2	GRIN2A	GRM3	GSK3B
HGF	H3C3	HNF1A	HSD3B1	HSP90AA1	IGF1R
IGF2	IKBKE	INHBA	INPP4B	IRF2	IRF4
IRS2	JUN	KAT6A	KDM5A	KDM5C	KDM6A
KDR	KEAP1	KEL	KLHL6	LMO1	LRP1B
LYN	LZTR1	MAGI2	MAP2K1	MAP2K2	MAP2K4
MAP3K1	MCL1	MED12	MEF2B	MEN1	MITF
MPL	MTOR	NF1	NF2	NFE2L2	NFKBIA
NKX2-1	NOTCH2	NOTCH3	NSD1	NUP93	PAK3
PAX5	PDCD1LG2	PIK3C2B	PIK3CG	PIK3R1	PIK3R2
PPP2R1A	PRDM1	PREX2	PRKAR1A	PRKCI	PRKDC
PRSS8	PTCH1	QKI	RAC1	RANBP2	RARA
RB1	RBM10	ROS1	RPTOR	RUNX1T1	SDHA
SDHB	SDHC	SDHD	SETD2	SLIT2	SMAD2
SMAD3	SMARCA4	SMARCB1	SNCAIP	SOCS1	SOX10
SOX2	SOX9	SPEN	SPOP	SPTA1	STAT3
STAT4	SUFU	SYK	TAF1	TBX3	TGFBR2
TNFAIP3	TNFRSF14	TOP1	TOP2A	TSC1	TSC2
TSHR	VEGFA	VHL	CCN6	XPO1	ZBTB2
ZNF217	ZNF703	EED	H3-3A	SUZ12	ABRAXAS1
GEN1	GREM1	HOXB13	ACVR1	ALOX12B	ANKRD11
ANKRD26	ARID5B	ASXL2	AXIN2	B2M	BBC3
BCL10	BCL2L11	BCR	BMPR1A	CALR	CASP8
CD276	CD74	CENPA	COP1	CSNK1A1	CTLA4
CUX1	DCUN1D1	DHX15	DIS3	DNAJB1	DNMT1
DNMT3B	E2F3	EGFL7	EIF1AX	EIF4A2	EIF4E
ELOC	EML4	ERCC3	ERCC5	ETS1	ETV1
ETV4	ETV5	EWSR1	FANCI	FLI1	FOXA1
FOXO1	FYN	GPS2	H1-2	H2BC5	H3-3B
H3-4	H3-5	H3C1	H3C10	H3C11	H3C12
H3C13	H3C14	H3C15	H3C4	H3C6	H3C7
H3C8	H3C2	HNRNPK	ICOSLG	ID3	IFNGR1
IGF1	IL10	INHA	INPP4A	INSR	IRS1
KIF5B	KLF4	LATS1	LATS2	MALT1	MAP3K13
MAP3K14	MAP3K4	MAPK1	MAPK3	MAX	MDC1
MGA	MSH3	MST1	MST1R	MYB	MYOD1
NAB2	NCOA3	NCOR1	NEGR1	NKX3-1	NOTCH4
NUTM1	PAK1	PAK5	PARP1	PAX3	PAX7
PAX8	PDCD1	PDPK1	PGR	PHOX2B	PIK3C2G
PIK3C3	PIK3CD	PIK3R3	PIM1	PLK2	PMAIP1
PMS1	PNRC1	PPARG	PPM1D	PPP2R2A	PPP6C
PRKN	PTPRD	PTPRS	PTPRT	RAB35	RAD21
RAD52	RASA1	RECQL4	REL	RHEB	RHOA
RIT1	RPS6KA4	RPS6KB2	RYBP	SDHAF2	SH2D1A
SHQ1	SMARCD1	SMC1A	SMC3	SOX17	STAG1
STAT5A	STAT5B	STK40	TCF3	TCF7L2	TET1
TFE3	TGFBR1	TMEM127	TMPRSS2	TP63	TRAF2
TRAF7	VTCN1	XIAP	YAP1	YES1	ZBTB7A
ZFHX3

CNVs
MET	RET	PTEN	FGFR2	PDGFRB	MYCN
ERBB2	MYCL1	AKT2	AR	MYC	ATM
BRCA1	BRCA2	CCND1	CCND3	CCNE1	CDK4
CDK6	CHEK1	CHEK2	EGFR	ERBB3	ERCC1
ERCC2	ALK	ESR1	FGF1	FGF10	FGF14
FGF19	FGF2	FGF23	FGF3	FGF4	FGF5
FGF6	FGF7	FGF8	FGF9	FGFR1	FGFR3
FGFR4	JAK2	KIT	KRAS	LAMP1	MDM2
MDM4	NRAS	NRG1	PDGFRA	PIK3CA	PIK3CB
RAF1	RICTOR	RPS6KB1	TFRC	CDK8	BRAF

Genomic Signatures
MSI	TMB	HRD

RNA Sequencing

Fusions
ABL1	CSF1R	ETV6	FGFR1	FLT3	JAK2
KMT2A	NTRK1	NTRK2	NTRK3	PDGFRA	PDGFRB
ALK	BRAF	EML4	EWSR1	FGFR2	FGFR3
RAF1	ROS1	FGFR4	NOTCH1	NOTCH2	NRG1
RET	BRCA1	BRCA2	CDK4	MSH2	PIK3CA
AKT3	AXL	ERBB2	ERG	ESR1	ETS1
ETV1	ETV4	ETV5	FLI1	FLT1	KDR
KIF5B	KIT	MYC	NOTCH3	PAX3	PAX7
PPARG	RPS6KB1	TMPRSS2	KMT2AT3

Splice Variant
EGFRvIII	MET exon 14 Skipping
EGFR	AR
MET	AR-V7

Immunohistochemistry (IHC)

Expression
FOLR1	Claudin-18	ALK	AR	ER	HER2
KI67	c-MET	PD-L1	TP53	PGR	PTEN
ROS1

Last Updated: February 12, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.