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NeoTYPE® AITL/Peripheral T-Cell Lymphoma Profile
- Next Generation Sequencing (NGS)
This panel is designed to detect key genetic alterations associated with angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma (PTCL) through next-generation sequencing (NGS) of all exons in the following genes:
DNA NGS (SNV/Indel):
IDH1, IDH2, DNMT3A, TET2, RHOA
Clinical Significance
Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma (PTCL) and accounts for 20-25% of PTCLs. Peripheral T-cell lymphoma is known as an aggressive group of lymphoid malignancies and represent about 10-15% of non-Hodgkin lymphomas. Frequent mutations have been detected in the genes IDH1/2, DNMT3A, TET2 and RHOA in patients diagnosed with AITL. These mutations may play a role in the pathogenesis of AITL/PTCLs.
Specimen Requirements
Bone Marrow Aspirate: 2 mL in EDTA tube.
Peripheral Blood: 5 mL in EDTA tube.
H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - TNA if specimen hold service is desired.
CPT Code(s)*
81450x1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 27, 2025