NeoTYPE® Lymphoid Disorders Profile

Next Generation Sequencing (NGS)

The NeoTYPE Lymphoid Disorders Profile is intended to aid in the diagnosis and subclassification of lymphoid neoplasms and to help identify potential therapies based on the patient’s unique molecular drivers.

This profile is designed to detect DNA mutations across 128 genes associated with a wide range of lymphoma and leukemia subtypes using next‑generation sequencing (NGS). Test reports include summary interpretation of all results to help guide treatment decisions.

Turnaround time

14 Days

Level of Service

Global

New York Approved: Yes

Clinical Significance

The NeoTYPE Lymphoid Disorders Profile is intended as an aid in the diagnosis and subclassification of lymphoid neoplasms as well as to identify potential therapies based on the patient's unique molecular drivers. The profile includes analysis of genes known to be recurrently mutated in chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), Richter's syndrome (RS), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), hairy cell leukemia (HCL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), double-hit lymphoma (DHL), and various T-cell neoplasms.

Specimen Requirements

Bone Marrow Aspirate: 2-3 mL in EDTA tube.
Peripheral Blood: 3-5 mL in EDTA tube.
H&E slide: Required, plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use: Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.

Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of collection. Please select Extract & Hold - TNA if specimen hold service is desired.

CPT Code(s)*

81455x1

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

SNVs + Indels
KMT2D	MAP2K1	PIK3CD	PIM1	MED12	MEF2B
MYC	PPM1D	MYCN	NF1	NOTCH2	NOTCH3
PIK3R1	PRDM1	REL	RHOA	RB1	SETD2
SOCS1	SPEN	STAT3	STAT5B	TNFAIP3	TNFRSF14
TCF3	XPO1	TRAF2	ARHGEF1	CIITA	DDX3X
EBF1	ABL1	EGR1	ABL2	CDKN2A	CRLF2
CSF1R	EPOR	FGFR3	GNAI2	IKZF1	STAT6
H1-4	JAK1	JAK2	JAK3	IKBKB	IKZF3
IRAK4	ITPKB	KLF2	PDGFRB	SH2B3	B2M
NFKBIE	TP53	ASXL1	NT5C2	BRAF	BCOR
P2RY8	DNMT3A	ETV6	EZH2	HRAS	IDH1
IDH2	PLCG1	POT1	KRAS	NRAS	PHF6
PTPN11	RUNX1	PRPS1	SF3B1	TET2	WT1
RIPK1	RPS15	S1PR2	SAMHD1	SGK1	TBL1XR1
TLR2	TRAF3	DIS3	UBR5	ZFHX4	ZMYM3
ARID1A	ATM	CTNNB1	GATA3	PIK3CA	PTEN
FAM46C	FOXO1	BCL2	BIRC3	BTK	CARD11
CD79B	CXCR4	MYD88	NOTCH1	PLCG2	FBXW7
ALK	ARID2	ID3	BCL6	CCND1	CCND2
CCND3	CD274	CD79A	CDKN1B	CDKN2B	CREBBP
CTCF	MALT1	MAP3K14	MAPK1	EP300	FAS
FAT1	GNA13

Last Updated: February 18, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.