NeoTYPE® Lymphoid Disorders Profile

Next Generation Sequencing (NGS)

The NeoTYPE Lymphoid Disorders Profile is intended to aid in the diagnosis and subclassification of lymphoid neoplasms and to help identify potential therapies based on the patient’s unique molecular drivers.

This profile is designed to detect DNA mutations across 128 genes associated with a wide range of lymphoma and leukemia subtypes using next‑generation sequencing (NGS). Test reports include summary interpretation of all results to help guide treatment decisions.

Turnaround time

14 Days

Level of Service

Global

New York Approved: Yes

Clinical Significance

The NeoTYPE Lymphoid Disorders Profile is intended as an aid in the diagnosis and subclassification of lymphoid neoplasms as well as to identify potential therapies based on the patient's unique molecular drivers. The profile includes analysis of genes known to be recurrently mutated in chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), Richter's syndrome (RS), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), hairy cell leukemia (HCL), follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), double-hit lymphoma (DHL), and various T-cell neoplasms.

Specimen Requirements

Bone Marrow Aspirate: 2-3 mL in EDTA tube.
Peripheral Blood: 3-5 mL in EDTA tube.
H&E slide: Required, plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use: Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.

Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of collection. Please select Extract & Hold - TNA if specimen hold service is desired.

CPT Code(s)*

81455x1

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

SNVs + Indels
ABL1	ABL2	ALK	ARHGEF1	ARID1A	ARID2
ASXL1	ATM	B2M	BCL2	BCL6	BCOR
BIRC3	BRAF	BTK	CARD11	CCND1	CCND2
CCND3	CD274	CD79A	CD79B	CDKN1B	CDKN2A
CDKN2B	CIITA	CREBBP	CRLF2	CSF1R	CTCF
CTNNB1	CXCR4	DDX3X	DIS3	DNMT3A	EBF1
EGR1	EP300	EPOR	ETV6	EZH2	FAM46C
FAS	FAT1	FBXW7	FGFR3	FOXO1	GATA3
GNA13	GNAI2	H1-4	HRAS	ID3	IDH1
IDH2	IKBKB	IKZF1	IKZF3	IRAK4	ITPKB
JAK1	JAK2	JAK3	KLF2	KMT2D	KRAS
MALT1	MAP2K1	MAP3K14	MAPK1	MED12	MEF2B
MYC	MYCN	MYD88	NF1	NFKBIE	NOTCH1
NOTCH2	NOTCH3	NRAS	NT5C2	P2RY8	PDGFRB
PHF6	PIK3CA	PIK3CD	PIK3R1	PIM1	PLCG1
PLCG2	POT1	PPM1D	PRDM1	PRPS1	PTEN
PTPN11	RB1	REL	RHOA	RIPK1	RPS15
RUNX1	S1PR2	SAMHD1	SETD2	SF3B1	SGK1
SH2B3	SOCS1	SPEN	STAT3	STAT5B	STAT6
TBL1XR1	TCF3	TET2	TLR2	TNFAIP3	TNFRSF14
TP53	TRAF2	TRAF3	UBR5	WT1	XPO1
ZFHX4	ZMYM3

Last Updated: March 02, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.