The NeoTYPE Head & Neck Tumor Profile analyzes 35 biomarkers through a combination of next-generation sequencing (NGS), other molecular methods, FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions.
NGS (27 genes + MSI and TMB)
Reflex rule: A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ?40% and paired normal tissue is available.
FISH – CNVs (3 probes)
MET, PTEN, RET
(tech-only available)
IHC (2 biomarkers)
* PD-L1 22C3 (tech-only available)
* Pan-TRK
Reflex rule: If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added.
Other Biomarkers (1 biomarker)
HPV RNA ISH 16/18 (High Risk)
NGS (27 genes + MSI and TMB)
Reflex rule: A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ?40% and paired normal tissue is available.
FISH – CNVs (3 probes)
MET, PTEN, RET
(tech-only available)
IHC (2 biomarkers)
* PD-L1 22C3 (tech-only available)
* Pan-TRK
Reflex rule: If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added.
Other Biomarkers (1 biomarker)
HPV RNA ISH 16/18 (High Risk)