Neo Comprehensive - Heme Cancers

The Neo Comprehensive - Heme Cancers profile is a DNA + RNA panel that detects known mutations, CNVs and RNA fusions associated with most forms of hematologic malignant disorders, such as acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic myelogenous leukemia (CML), angioimmunoblastic T-cell lymphoma (AITL)/peripheral T-cell lymphoma (PTCL), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), T/NK-large granular lymphocytic leukemia, among others.

Testing using this panel can provide key diagnostic information, including critical molecular determinations affecting therapeutic approaches, can aid in risk stratification and predicting prognosis, and can also be used in clinical research.

Bone Marrow Aspirate: 2-3 mL in EDTA tube.
Peripheral Blood: 3-5 mL in EDTA tube.
H&E slide: Required, plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use: Mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA if specimen hold service is desired.