Neo Comprehensive - Heme Cancers

The Neo Comprehensive - Heme Cancers assay analyzes 433 genes to detect DNA and RNA alterations through next-generation sequencing (NGS).

DNA NGS (SNV/Indel):
ABL1, ABL2, AKT1, AKT2, AKT3, ALK, ANKRD26, APC, ARAF, ARHGEF1, ARID1A, ARID1B, ARID2, ASXL1, ASXL2, ATG2B, ATM, ATP2A2, ATRX, AXL, B2M, BAP1, BCL2, BCL2L11, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BRAF, BRCA1, BRCA2, BRINP3, BRIP1, BTK, C17orf97, CALR, CARD11, CBFB, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CD274, CD33, CD79A, CD79B, CDC25C, CDK2, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CEBPA, CHEK2, CIC, CIITA, CREBBP, CRLF2, CSF1R, CSF3R, CTC1, CTCF, CTNNB1, CUX1, CXCR4, CYLD, DAXX, DCK, DDX3X, DDX41, DIS3, DKC1, DNMT1, DNMT3A, EBF1, EED, EGFR, EGLN1, EGR1, ELANE, EP300, EPCAM, EPHA2, EPHA7, EPOR, ERBB2, ERBB3, ERCC4, ETNK1, ETV6, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXO1, FUBP1, G6PC3, GAB2, GATA1, GATA2, GATA3, GFI1, GNA12, GNA13, GNAI2, GNAQ, GNAS, GNB1, GSKIP, H1-4, HAX1, HIF1A, HNRNPK, HRAS, ID3, IDH1, IDH2, IGF1R, IKBKB, IKZF1, IKZF3, IL7R, IRAK4, IRF4, ITPKB, JAK1, JAK2, JAK3, KDM6A, KDR, KEAP1, KIT, KLF2, KLHL6, KMT2A, KMT2C, KMT2D, KRAS, LUC7L2, MALT1, MAP2K1, MAP3K1, MAP3K14, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MET, MLH1, MPL, MSH2, MSH6, MTOR, MYC, MYCN, MYD88, NBN, NCAPH, NF1, NFKBIE, NHP2, NOP10, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NSD1, NT5C2, NTRK1, NTRK2, NTRK3, NUP214, NUP98, P2RY8, PALB2, PAX5, PDCD1LG2, PDGFRA, PDGFRB, PHF6, PIGA, PIK3CA, PIK3CD, PIK3R1, PIM1, PLCG1, PLCG2, PML, PMS2, POT1, PPM1D, PRDM1, PRPF40B, PRPF6, PRPF8, PRPS1, PTCH1, PTEN, PTPN11, PTPRC, RAC1, RAD21, RAD51C, RAD51D, RB1, RBBP6, REL, RHEB, RHOA, RICTOR, RIPK1, RIT1, RPL11, RPL35A, RPL5, RPN1, RPS10, RPS15, RPS17, RPS26, RPS7, RTEL1, RUNX1, S1PR2, SAMD9, SAMD9L, SAMHD1, SBDS, SETBP1, SETD2, SF1, SF3A1, SF3B1, SGK1, SH2B3, SLX4, SMAD4, SMARCB1, SMC1A, SMC3, SMO, SOCS1, SPEN, SRP72, SRSF2, STAG2, STAT3, STAT5B, STAT6, STK11, SUZ12, TBL1XR1, TCF3, TENT5C, TERC, TERT, TET2, TET3, THPO, TINF2, TLR2, TNFAIP3, TNFRSF14, TP53, TP63, TRAF2, TRAF3, TSC1, TSC2, U2AF1, U2AF2, UBR5, VHL, WAS, WRAP53, WT1, XPO1, ZFHX4, ZMYM3, ZRSR2

DNA NGS (CNV):
ABL1, ASXL1, ATM, BRAF, CBL, CD274, CDKN1B, CDKN2A, DNMT1, EPOR, ETV6, EZH2, FLT3, IKZF1, JAK2, KMT2A, KRAS, MYC, PAX5, RAD21, REL, TNFRSF14, TP53, XPO1

RNA NGS (Fusion):
ABI1, ABL1, ABL2, ACTN4, ADAMTS17, AFDN, AFF1, AFF3, AGGF1, ALK, ARHGAP26, ARHGEF12, ATF7IP, ATIC, ATP2A1, ATP5MG, BCL11B, BCL2, BCL6, BCR, BIN2, BIRC3, CALR, CAPRIN1, KNL1, CBFB, CBL, CCDC6, CCDC88C, CCND1, CCND2, CCND3, CDK6, CEP43, CEP85L, CHD1, CHIC2, CIITA, CNTRL, COL1A1, CPSF6, CREBBP, CRLF2, CSF1R, CXCR4, DEK, DTD1, DUSP22, EBF1, EIF4A1, ELL, EML1, EP300, EPOR, EPS15, ERC1, ERG, ERVK3, ETV6, FGFR1, FGFR1OP2, FIP1L1, FLT3, FNBP1, FOXO4, FOXP1, FRYL, FUS, GAS7, GIT2, GLIS2, GOLGA4, GPHN, HIP1, HLF, HNRNPA2B1, IKZF1, IKZF2, IKZF3, JAK2, KANK1, KAT6A, KLF2, KMT2A, LAIR1, LMNA, LRRFIP1, MALT1, MAML2, MAP4, MECOM, MEF2D, MRTFA, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MYB, MYC, MYH11, MYO18A, MYO1F, NDE1, NF1, NFKB2, NIN, NOTCH1, NOTCH2, NPM1, NRIP1, NTRK1, NTRK2, NTRK3, NUP214, NUP98, P2RY8, PAG1, PAX5, PBX1, PCM1, PDCD1LG2, PDE4DIP, PDGFRA, PDGFRB, PICALM, PLAG1, PML, PRDM16, PRDM9, PRKG2, PTK2B, PVT1, RABEP1, RARA, RBM15, RBM6, RCSD1, ROS1, RPN1, RUNX1, RUNX1T1, SART3, SEMA6A, SEPTIN2, SEPTIN3, SEPTIN5, SEPTIN6, SEPTIN9, SEPTIN12, SETD2, SNX2, SPECC1, SPTBN1, SQSTM1, SSBP2, STIL, SYNRG, TACC1, TAL1, TBL1XR1, TCF3, TERF2, TET1, TFG, TLX1, TLX3, TP53BP1, TP63, TPM3, TPR, TRIM24, TRIP11, TYK2, UBE2R2, WDR48, ZBTB16, ZCCHC7, ZEB2, ZMIZ1, ZMYM2, ZNF384, ZNF703

Test Customization: FLT3 by PCR (via FLT3 Mutation Analysis) is available for concurrent testing as a Client-Bill option. It is reported separately to support prompt therapy selection in newly diagnosed AML cases.