Neo Comprehensive - Heme Cancers

The Neo Comprehensive- Heme Cancers assay analyzes 433 genes to detect DNA and RNA alterations through NGS for the purpose of diagnostic evaluation, prognosis, risk stratification, and therapy guidance of hematologic malignancies.

DNA NGS (SNV/Indel):
ABL1, ABL2, AKT1, AKT2, AKT3, ALK, ANKRD26, APC, ARAF, ARHGEF1, ARID1A, ARID1B, ARID2, ASXL1, ASXL2, ATG2B, ATM, ATP2A2, ATRX, AXL, B2M, BAP1, BCL2, BCL2L11, BCL6, BCOR, BCORL1, BCR, BIRC3, BLM, BRAF, BRCA1, BRCA2, BRINP3, BRIP1, BTK, C17orf97, CALR, CARD11, CBFB, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CD274, CD33, CD79A, CD79B, CDC25C, CDK2, CDK4, CDK6, CDKN1B, CDKN2A, CDKN2B, CEBPA, CHEK2, CIC, CIITA, CREBBP, CRLF2, CSF1R, CSF3R, CTC1, CTCF, CTNNB1, CUX1, CXCR4, CYLD, DAXX, DCK, DDX3X, DDX41, DIS3, DKC1, DNMT1, DNMT3A, EBF1, EED, EGFR, EGLN1, EGR1, ELANE, EP300, EPCAM, EPHA2, EPHA7, EPOR, ERBB2, ERBB3, ERCC4, ETNK1, ETV6, EZH2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FAS, FAT1, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXO1, FUBP1, G6PC3, GAB2, GATA1, GATA2, GATA3, GFI1, GNA12, GNA13, GNAI2, GNAQ, GNAS, GNB1, GSKIP, H1-4, HAX1, HIF1A, HNRNPK, HRAS, ID3, IDH1, IDH2, IGF1R, IKBKB, IKZF1, IKZF3, IL7R, IRAK4, IRF4, ITPKB, JAK1, JAK2, JAK3, KDM6A, KDR, KEAP1, KIT, KLF2, KLHL6, KMT2A, KMT2C, KMT2D, KRAS, LUC7L2, MALT1, MAP2K1, MAP3K1, MAP3K14, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MET, MLH1, MPL, MSH2, MSH6, MTOR, MYC, MYCN, MYD88, NBN, NCAPH, NF1, NFKBIE, NHP2, NOP10, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NSD1, NT5C2, NTRK1, NTRK2, NTRK3, NUP214, NUP98, P2RY8, PALB2, PAX5, PDCD1LG2, PDGFRA, PDGFRB, PHF6, PIGA, PIK3CA, PIK3CD, PIK3R1, PIM1, PLCG1, PLCG2, PML, PMS2, POT1, PPM1D, PRDM1, PRPF40B, PRPF6, PRPF8, PRPS1, PTCH1, PTEN, PTPN11, PTPRC, RAC1, RAD21, RAD51C, RAD51D, RB1, RBBP6, REL, RHEB, RHOA, RICTOR, RIPK1, RIT1, RPL11, RPL35A, RPL5, RPN1, RPS10, RPS15, RPS17, RPS26, RPS7, RTEL1, RUNX1, S1PR2, SAMD9, SAMD9L, SAMHD1, SBDS, SETBP1, SETD2, SF1, SF3A1, SF3B1, SGK1, SH2B3, SLX4, SMAD4, SMARCB1, SMC1A, SMC3, SMO, SOCS1, SPEN, SRP72, SRSF2, STAG2, STAT3, STAT5B, STAT6, STK11, SUZ12, TBL1XR1, TCF3, TENT5C, TERC, TERT, TET2, TET3, THPO, TINF2, TLR2, TNFAIP3, TNFRSF14, TP53, TP63, TRAF2, TRAF3, TSC1, TSC2, U2AF1, U2AF2, UBR5, VHL, WAS, WRAP53, WT1, XPO1, ZFHX4, ZMYM3, ZRSR2

DNA NGS (CNV):
ABL1, ASXL1, ATM, BRAF, CBL, CD274, CDKN1B, CDKN2A, DNMT1, EPOR, ETV6, EZH2, FLT3, IKZF1, JAK2, KMT2A, KRAS, MYC, PAX5, RAD21, REL, TNFRSF14, TP53, XPO1

RNA NGS (Fusion):
ABI1, ABL1, ABL2, ACTN4, ADAMTS17, AFDN, AFF1, AFF3, AGGF1, ALK, ARHGAP26, ARHGEF12, ATF7IP, ATIC, ATP2A1, ATP5MG, BCL11B, BCL2, BCL6, BCR, BIN2, BIRC3, CALR, CAPRIN1, KNL1, CBFB, CBL, CCDC6, CCDC88C, CCND1, CCND2, CCND3, CDK6, CEP43, CEP85L, CHD1, CHIC2, CIITA, CNTRL, COL1A1, CPSF6, CREBBP, CRLF2, CSF1R, CXCR4, DEK, DTD1, DUSP22, EBF1, EIF4A1, ELL, EML1, EP300, EPOR, EPS15, ERC1, ERG, ERVK3, ETV6, FGFR1, FGFR1OP2, FIP1L1, FLT3, FNBP1, FOXO4, FOXP1, FRYL, FUS, GAS7, GIT2, GLIS2, GOLGA4, GPHN, HIP1, HLF, HNRNPA2B1, IKZF1, IKZF2, IKZF3, JAK2, KANK1, KAT6A, KLF2, KMT2A, LAIR1, LMNA, LRRFIP1, MALT1, MAML2, MAP4, MECOM, MEF2D, MRTFA, MLF1, MLLT1, MLLT10, MLLT11, MLLT3, MLLT6, MYB, MYC, MYH11, MYO18A, MYO1F, NDE1, NF1, NFKB2, NIN, NOTCH1, NOTCH2, NPM1, NRIP1, NTRK1, NTRK2, NTRK3, NUP214, NUP98, P2RY8, PAG1, PAX5, PBX1, PCM1, PDCD1LG2, PDE4DIP, PDGFRA, PDGFRB, PICALM, PLAG1, PML, PRDM16, PRDM9, PRKG2, PTK2B, PVT1, RABEP1, RARA, RBM15, RBM6, RCSD1, ROS1, RPN1, RUNX1, RUNX1T1, SART3, SEMA6A, SEPTIN2, SEPTIN3, SEPTIN5, SEPTIN6, SEPTIN9, SEPTIN12, SETD2, SNX2, SPECC1, SPTBN1, SQSTM1, SSBP2, STIL, SYNRG, TACC1, TAL1, TBL1XR1, TCF3, TERF2, TET1, TFG, TLX1, TLX3, TP53BP1, TP63, TPM3, TPR, TRIM24, TRIP11, TYK2, UBE2R2, WDR48, ZBTB16, ZCCHC7, ZEB2, ZMIZ1, ZMYM2, ZNF384, ZNF703

Test Customization: FLT3 by PCR (via FLT3 Mutation Analysis) is available for concurrent testing as a Client-Bill option. It is reported separately to support prompt therapy selection in newly diagnosed AML cases.