Neo Comprehensive - Solid Tumor

Next Generation Sequencing (NGS)

Neo Comprehensive - Solid Tumor is now NEO PanTracer Tissue

Turnaround time

8-10 Days

NGS: 8-10 Days
IHC: 2 Days

Level of Service

Global

New York Approved: Yes

Specimen Requirements

A block is preferred for testing: >20% tumor and >10 mm2 of tissue surface area for NGS (~500 tumor cells)(additional 100 neoplastic cells for PD-L1). If submitting 5-micron unstained slides, the following number of slides are requested: Samples with >25 mm2 of tissue: 10 unstained slides (2 sections per slide preferred) Samples with 10-24 mm2 of tissue: 20 unstained slides (2 sections per slide preferred) Please submit 1 additional unstained slide for H&E and 3 additional unstained slides if performing PD-L1 testing.

Storage and Transportation

Storage & Transportation: Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

CPT Code(s)*

81459x1. Add 88360x1 for PD-L1 IHC.

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Biomarkers

DNA Sequencing

CNVs
MET	RET	PTEN	FGFR2	MYCN	ERBB2
AKT2	AR	ATM	BRCA1	BRCA2	CCND1
CCND3	CCNE1	CDK4	CDK6	CHEK1	CHEK2
EGFR	ERBB3	ERCC1	ERCC2	ESR1	FGF1
FGF10	FGF14	FGF19	FGF2	FGF23	FGF3
FGF4	FGF5	FGF6	FGF7	FGF8	FGF9
FGFR1	FGFR3	FGFR4	JAK2	KIT	KRAS
LAMP1	MDM2	MDM4	MYCL	NRAS	NRG1
PDGFRA	0	PIK3CA	PIK3CB	RAF1	RICTOR
RPS6KB1	TFRC

SNVs + Indels
ABL1	ABL2	CDKN2A	CRLF2	CSF1R	FGFR2
FGFR3	FLT3	IKZF1	IL7R	JAK1	JAK2
JAK3	NTRK1	NTRK2	NTRK3	PDGFRA	PDGFRB
SH2B3	TP53	ASXL1	BCOR	BRAF	CEBPA
CSF3R	DNMT3A	ETV6	EZH2	HRAS	IDH1
IDH2	KIT	KMT2A	KRAS	NPM1	NRAS
PHF6	PTPN11	RUNX1	SETBP1	SF3B1	SRSF2
STAG2	TET2	U2AF1	WT1	ZRSR2	BRCA2
BRIP1	DDX41	ERCC4	PALB2	RAD51C	SLX4
TERC	TERT	XRCC2	AKT1	ARID1A	ATM
ATR	BARD1	BRCA1	CDH1	CDK12	CHEK1
CHEK2	CTNNB1	EGFR	ERBB2	ERBB4	ESR1
FANCA	FANCC	FANCD2	FANCE	FANCF	FANCG
FANCL	FGFR1	GATA3	MET	MLH1	MRE11
MSH2	MSH6	NBN	PIK3CA	PMS2	PTEN
RAD50	RAD51	RAD51B	RAD51D	RAD54L	SMAD4
SMO	SRC	APC	BAP1	PBRM1	BCL2
BIRC3	BTK	CARD11	CD79B	CXCR4	MYD88
NOTCH1	PLCG2	EPCAM	FBXW7	MUTYH	POLD1
POLE	RNF43	STK11	ATRX	ACVR1B	AKT2
AKT3	ALK	AMER1	AR	ARAF	ARFRP1
ARID1B	ARID2	AURKA	AURKB	AXIN1	AXL
BCL2L1	BCL2L2	BCL6	BCORL1	BLM	BRD4
BTG1	EMSY	CBFB	CBL	CCND1	CCND2
CCND3	CCNE1	CD274	CD79A	CDC73	CDK4
CDK6	CDK8	CDKN1A	CDKN1B	CDKN2B	CDKN2C
CHD2	CHD4	CIC	CREBBP	CRKL	CTCF
CTNNA1	CUL3	CYLD	DAXX	DDR2	DICER1
DOT1L	EP300	EPHA3	EPHA5	EPHA7	EPHB1
ERBB3	ERG	ERRFI1	TENT5C	FAS	FAT1
FGF10	FGF14	FGF19	FGF23	FGF3	FGF4
FGF6	FGFR4	FH	FLCN	FLT1	FLT4
FOXL2	FOXP1	FRS2	FUBP1	GABRA6	GATA1
GATA2	GATA4	GATA6	GID4	GLI1	GNA11
GNA13	GNAQ	GNAS	ADGRA2	GRIN2A	GRM3
GSK3B	HGF	H3C3	HNF1A	HSD3B1	HSP90AA1
IGF1R	IGF2	IKBKE	INHBA	INPP4B	IRF2
IRF4	IRS2	JUN	KAT6A	KDM5A	KDM5C
KDM6A	KDR	KEAP1	KEL	KLHL6	KMT2C
KMT2D	LMO1	LRP1B	LYN	LZTR1	MAGI2
MAP2K1	MAP2K2	MAP2K4	MAP3K1	MCL1	MDM2
MDM4	MED12	MEF2B	MEN1	MITF	MPL
MTOR	MYC	MYCL	MYCN	NF1	NF2
NFE2L2	NFKBIA	NKX2-1	NOTCH2	NOTCH3	NSD1
NUP93	PAK3	PAX5	PDCD1LG2	PDK1	PIK3C2B
PIK3CB	PIK3CG	PIK3R1	PIK3R2	PPP2R1A	PRDM1
PREX2	PRKAR1A	PRKCI	PRKDC	PRSS8	PTCH1
QKI	RAC1	RAF1	RANBP2	RARA	RB1
RBM10	RET	RICTOR	ROS1	RPTOR	RUNX1T1
SDHA	SDHB	SDHC	SDHD	SETD2	SLIT2
SMAD2	SMAD3	SMARCA4	SMARCB1	SNCAIP	SOCS1
SOX10	SOX2	SOX9	SPEN	SPOP	SPTA1
STAT3	STAT4	SUFU	SYK	TAF1	TBX3
TGFBR2	TNFAIP3	TNFRSF14	TOP1	TOP2A	TSC1
TSC2	TSHR	VEGFA	VHL	CCN6	XPO1
ZBTB2	ZNF217	ZNF703	EED	H3-3A	SUZ12
ABRAXAS1	GEN1	GREM1	HOXB13	ACVR1	ALOX12B
ANKRD11	ANKRD26	ARID5B	ASXL2	AXIN2	B2M
BBC3	BCL10	BCL2L11	BCR	BMPR1A	CALR
CASP8	CD276	CD74	CENPA	COP1	CSNK1A1
CTLA4	CUX1	DCUN1D1	DHX15	DIS3	DNAJB1
DNMT1	DNMT3B	E2F3	EGFL7	EIF1AX	EIF4A2
EIF4E	ELOC	EML4	ERCC1	ERCC2	ERCC3
ERCC5	ETS1	ETV1	ETV4	ETV5	EWSR1
FANCI	FGF1	FGF2	FGF5	FGF7	FGF8
FGF9	FLI1	FOXA1	FOXO1	FYN	GPS2
H1-2	H2BC5	H3-3B	H3-4	H3-5	H3C1
H3C10	H3C11	H3C12	H3C13	H3C14	H3C15
H3C4	H3C6	H3C7	H3C8	H3C2	HNRNPK
ICOSLG	ID3	IFNGR1	IGF1	IL10	INHA
INPP4A	INSR	IRS1	KIF5B	KLF4	LAMP1
LATS1	LATS2	MALT1	MAP3K13	MAP3K14	MAP3K4
MAPK1	MAPK3	MAX	MDC1	MGA	MLLT3
MSH3	MST1	MST1R	MYB	MYOD1	NAB2
NCOA3	NCOR1	NEGR1	NKX3-1	NOTCH4	NRG1
NUTM1	PAK1	PAK5	PARP1	PAX3	PAX7
PAX8	PDCD1	PDPK1	PGR	PHOX2B	PIK3C2G
PIK3C3	PIK3CD	PIK3R3	PIM1	PLK2	PMAIP1
PMS1	PNRC1	PPARG	PPM1D	PPP2R2A	PPP6C
PRKN	PTPRD	PTPRS	PTPRT	RAB35	RAD21
RAD52	RASA1	RECQL4	REL	RHEB	RHOA
RIT1	RPS6KA4	RPS6KB1	RPS6KB2	RYBP	SDHAF2
SH2D1A	SHQ1	SMARCD1	SMC1A	SMC3	SOX17
STAG1	STAT5A	STAT5B	STK40	TCF3	TCF7L2
TET1	TFE3	TFRC	TGFBR1	TMEM127	TMPRSS2
TP63	TRAF2	TRAF7	VTCN1	XIAP	YAP1
YES1	ZBTB7A	ZFHX3

Genomic Signatures
MSI	TMB

RNA Sequencing

Fusions
ABL1	BCR	CSF1R	ETV6	FGFR1	FLT3
JAK2	KMT2A	MLLT10	NTRK1	NTRK2	NTRK3
NUP98	PBX1	PDGFRA	PDGFRB	RUNX1	TAL1
TCF3	ALK	BRAF	CIC	EGFR	EML4
EWSR1	FGFR2	FGFR3	FUS	KIAA1549	MAML2
MET	MN1	MYB	MYBL1	RAF1	ROS1
STAT6	TACC3	TFG	YAP1	ZFTA	FGFR4
NOTCH1	NOTCH2	NRG1	PDGFB	RET	BRCA1
BRCA2	CDK4	MSH2	MYH9	PIK3CA	WT1
ACSL3	ACTB	ACTL6A	AFDN	AFF1	AFF3
AFF4	AHRR	AKAP9	AKT3	AR	ARID1A
ASPSCR1	ATF1	ATIC	AXL	BCL2	BCOR
BRD4	CAMTA1	CANT1	CAPZA2	CARS1	CBFA2T3
CCDC170	CCDC6	CCNB3	CCND1	CCND2	CCND3
CD274	CD74	CDH11	CDK6	CDKN2D	CHCHD7
CIITA	CLTC	CNBP	COA5	COL1A1	COL1A2
CREB1	CREB3L1	CREB3L2	CREBBP	CRTC1	CRTC3
CSF1	CTLA4	CTNNB1	CTNNBL1	DDIT3	DDX3X
DDX5	DHH	DNAJB1	DUX4	ELK4	ELL
EPC1	EPS15	ERBB2	ERG	ESR1	ESRP1
ETS1	ETV1	ETV4	ETV5	EZR	FAM131B
FEV	FLI1	FLT1	FOXO1	FOXP1	FRK
GLI1	GLIS1	GLIS2	GLIS3	GNAS	GOPC
HAS2	HERPUD1	HEY1	HIP1	HMGA2	HMGN2P46
HNRNPA2B1	IL2RB	IRF4	ITK	JAZF1	KAT6A
KDM5A	KDR	KIF5B	KIT	KLK2	KNL1
KRAS	LIFR	LMNA	LPP	MAML1	MAST1
MAST2	MEAF6	MKRN1	MLLT1	MLLT11	MLLT3
MPRIP	MRTFB	MYC	MYLK	NAB2	NCOA1
NCOA2	NCOA4	NDRG1	NFATC2	NFIB	NOTCH3
NPM1	NR4A3	NUP214	NUTM1	NUTM2A	NUTM2B
OMD	PAN3	PATZ1	PAX3	PAX7	PAX8
PCM1	PHF1	PLAG1	PML	POU5F1	PPARG
PRCC	PRKACA	PRKAR1A	PRKD1	PRKD2	PRKD3
PTPRK	RAD51B	RANBP2	RARA	RASGEF1A	RHEBL1
RPS6KB1	RPS6KC1	RSPO3	RUNX1T1	SDC4	SEC31A
SEPTIN6	SEPTIN9	SET	SLC34A2	SLC45A3	SND1
SNURF	SRF	SRGAP3	SS18	SSX1	SSX2
SSX4B	STIL	STRN	SUZ12	SYK	TAF15
TBL1XR1	TCF12	TCF7L2	TEAD1	TEAD2	TEAD3
TFE3	THADA	THRAP3	TMPRSS2	TP63	TPM3
TPM4	TPR	TRIM24	UBTF	USP6	VTI1A
WDFY2	WIF1	WWTR1	YWHAE	ZNF444

Splice Variant
MET

Fluorescence In Situ Hybridization (FISH)

Structural Rearrangement(s)
ALK	BRAF

Amplification(s)
MYC

Immunohistochemistry (IHC)

Expression
CD274

Last Updated: January 19, 2026

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.