NeoTYPE® GIST and Soft Tissue Tumor Profile

The NeoTYPE GIST/Soft Tissue Tumor Profile analyzes 43 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. A microsatellite instability (MSI) NGS result of "indeterminate" will create a reflex to MSI by PCR as long as the tumor percentage is ≥40% and paired normal tissue is available. NGS (38 genes + 2 biomarkers): AKT1, AKT2, AKT3, ARID1A, ATM, BRAF, CDKN2A, CTNNB1, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, GNAS, HRAS, KIT, KRAS, MAP2K1, MET, Microsatellite Instability (MSI), NF1, NRAS, NTRK1 fusions, NTRK2 fusions, NTRK3 fusions, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, SDHA, SDHB, SDHC, SDHD, SMAD4, SMO, SRC, TERT Promoter, TP53, Tumor Mutation Burden (TMB) FISH (2 FISH): MET, PTEN (tech-only available) IHC (1 biomarker): PD-L1 LDT (tech-only available).