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NeoTYPE® Follicular Lymphoma Profile
- Next Generation Sequencing (NGS)
This panel is designed to detect key genetic abnormalities associated with follicular lymphoma through next-generation sequencing (NGS) and fluorescence in situ hybridization (FISH). It includes the following components:
DNA NGS (SNV/Indel):
ARID1A, BCL2, BCL6, CDKN2A, CREBBP, EP300, EZH2*, FAS, KMT2D, MAP2K1, MEF2B, PIK3CA, SOCS1, STAT6, TNFAIP3, TNFRSF14
*EZH2 mutations detected include Y646N, Y646H, Y646F, Y646S, Y646C, A682G, and A692V (Exons 16 and 18).
FISH Probes:
IgH/BCL2 t(14;18)
DUSP22-IRF4 (6p25.3)
TNFRSF14 (1p36)
Test Customization: FISH components may be ordered separately as Tech-Only by pathology clients.
Specimen Requirements
H&E slide (required) plus paraffin block.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - TNA if specimen hold service is desired.
CPT Code(s)*
81450x1; 88374x3 or 88377x3
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 05, 2025