The NEO | AML Express assay is a next-generation sequencing (NGS) assay using combined DNA- and RNA-sequencing, which is used to identify prognostically and diagnostically informative alterations in acute myeloid leukemia (AML). The DNA sequencing component of this assay detects single nucleotide variants (SNVs) and indels in genes recurrently mutated in AML, and the RNA sequencing component detects fusions involving genes that are frequently involved in structural rearrangements observed in AML, as noted below. Test reports include summary interpretation of all results to help guide treatment decisions.
NEO AML Express
- Next Generation Sequencing (NGS)
- Epic Aura Integration
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in EDTA tube.
Peripheral Blood: 2-3 mL in EDTA tube.
Note on fresh samples: NeoGenomics should receive within 7 days from collection for acceptable cell viability.
Storage and Transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Note: To ensure fast TAT and sample stability, ship samples directly to NeoGenomics Houston (non-NY samples) or Ramsey (NY samples).
CPT Code(s)*
Client-Bill Only
Turnaround time
5 Days
Level of Service
- Global
Integrations
- Epic Aura
New York Approved: Yes
Clinical Significance
In conjunction with clinical features and other laboratory results, molecular profiling with the NEO Express AML panel may facilitate risk stratification and therapy selection for patients with newly diagnosed AML.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| SNVs + Indels | |||||
|---|---|---|---|---|---|
| ABL1 | ASXL1 | BCOR | BRAF | CALR | CBL |
| CEBPA | CSF3R | DDX41 | DNMT3A | ETV6 | EZH2 |
| FLT3 | GATA2 | HRAS | IDH1 | IDH2 | JAK2 |
| KIT | KRAS | MPL | NF1 | NPM1 | NRAS |
| PHF6 | PPM1D | PRPF8 | PTPN11 | RUNX1 | SETBP1 |
| SF3B1 | SRSF2 | STAG2 | TET2 | TP53 | U2AF1 |
| WT1 | ZRSR2 | ||||
RNA Sequencing
| Fusions | |||||
|---|---|---|---|---|---|
| ABL1 | KAT6A | KMT2A | MECOM | MYH11 | NUP214 |
| NUP98 | RARA | RUNX1 | |||
Last Updated: March 18, 2026