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NeoTYPE® ALL Profile
- Next Generation Sequencing (NGS)
The NeoTYPE ALL Profile analyzes 50 genes to detect DNA and RNA alterations through a combination of next-generation sequencing (NGS) and FISH as noted below. Test reports include a summary interpretation of all results together. FISH components may be ordered as "Tech-Only" by pathology clients who wish to perform the professional component.
DNA Sequencing: SNVs/InDels (29 Genes): ABL1, ABL2, CDKN2A, CRLF2, CSF1R, EPOR, FBXW7, FGFR2, FGFR3, FLT3, IDH1, IDH2, IKZF1, IL7R, JAK1, JAK2, JAK3, KRAS, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PAX5, PDGFRA, PDGFRB, PHF6, SH2B3, and TP53
Copy Number Variations (3 Genes): CDKN2A, IKZF1, and TP53 Note: Only copy number loss is reported as it is a clinically relevant abnormality for these tumor suppressor genes.
RNA Sequencing: Fusions (34 Genes): ABL1, ABL2, BCL11B, BCR, CRLF2, CSF1R, EPOR, ETV6, FGFR1, FLT3, IKZF1, JAK2, KMT2A, MEF2D, MLLT10, MYB, NTRK1, NTRK2, NTRK3, NUP214, NUP98, PAX5, PBX1, PDGFRA, PDGFRB, PTK2B, RUNX1, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, and ZNF384
FISH (2 Genes): CRLF2 (Xp22.33/Yp11.32) | EPOR (19p13.2)
Specimen Requirements
Bone Marrow Aspirate: 2-3 mL in EDTA tube.
Peripheral Blood: 3-5 mL in EDTA tube.
H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 10-14 unstained slides cut at 5+ microns.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Do not use mercury fixatives (B5). Highly acidic or prolonged decalcification processes will not yield sufficient nucleic acid to accurately perform molecular studies.
Note: Test is TNA-based. Please select Extract & Hold - TNA If specimen hold service is desired.
Note for FFPE: Not validated specimen type for FISH testing.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - TNA if specimen hold service is desired.
CPT Code(s)*
81450x1, 88374x2
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: July 28, 2025