CALR Mutation Analysis by NGS

Next-generation sequencing of exon 9 of the CALR (calreticulin) gene for enhanced detection of low levels of insertion/deletion mutations. This test may be ordered separately (if JAK2 analysis, specifically JAK2 V617F, is already performed), as a reflex from JAK2 V617F Mutation Analysis, or as part of the MPN JAK2 V617F with Sequential Reflex to JAK2 Exon 12-15, CALR, and MPL.

Note: This assay replaces the former Calreticulin (CALR) Mutation Analysis performed by fragment analysis/bi-directional sequencing. NY samples are still processed by fragment analysis/bi-directional sequencing until further notice.