This test uses PCR on variable and joining regions to detect clonal T-cell receptor (TCR) gamma gene rearrangements.
Test Customization: This test may be ordered concurrently with the T-Cell Receptor Beta Gene Rearrangement assay.
T-Cell Receptor Gamma Gene Rearrangement
- Molecular
Specimen Requirements
Bone Marrow Aspirate: 2 mL in EDTA tube.
Peripheral Blood: 5 mL in EDTA tube.
H&E slide: H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 4-5 unstained slides cut at 5+ microns.
Fresh, Unfixed Tissue: Two pieces minimum, 0.2 cm3 in RPMI.
Note on FFPE: Paraffin block is preferred. Do not use zinc fixatives. If submitting slides, please use positively-charged slides and 10% NBF fixative. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Note: Test is DNA-based. Please select Extract & Hold - DNA If specimen hold service is desired.
Note on Fresh Tissue: Not suitable for freeze & hold option.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. Please select extract & hold - DNA if specimen hold service is desired. NYS clients please provide date and time of collection.
CPT Code(s)*
81342
Turnaround time
7 Days
Level of Service
- Global
Integrations
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New York Approved: Yes
Clinical Significance
T-cell receptor (TCR) gene rearrangement analysis is commonly used for determining clonality in the diagnostic evaluation of T-cell lymphomas and leukemias. TCR beta gene (tested separately) and gamma gene rearrangement analysis (as provided in this test) together will detect most clonal TCR rearrangements in patients with T-cell lymphomas/leukemias. Results should be interpreted in clinical context for diagnosis of T-cell lymphoproliferative disorders.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Polymerase Chain Reaction (PCR)
| Rearrangement(s) | |||||
|---|---|---|---|---|---|
| TCR gamma | |||||
Last Updated: January 23, 2026