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Sarcoma Comprehensive NGS Fusion Panel
- Next Generation Sequencing (NGS)
The Sarcoma Comprehensive NGS Fusion Panel is an RNA-based next-generation sequencing panel that detects translocations and fusions with known and novel fusion partners of these genes: ACTB, AHRR, ALK, ASPSCR1, ATF1, ATIC, BCOR, BRAF, C11orf95, CAMTA1, CARS1, CCNB3, CDH11, CIC, CLTC, CNBP, COL1A1, COL1A2, CREB1, CREB3L1, CREB3L2, CSF1, CTNNB1, DDIT3, DUX4, EML4, EPC1, ERG, ETV1, ETV4, ETV6, EWSR1, FEV, FLI1, FOXO1, FRK, FUS, GLI1, HAS2, HEY1, HMGA2, IL2RB, ITK, JAZF1, LMNA, LPP, MEAF6, MRTFB, MYH9, MYLK, NAB2, NCOA1, NCOA2, NFATC2, NFIB, NR4A3, NTRK1, NTRK2, NTRK3, NUTM2A, NUTM2B, OMD, PAX3, PATZ1, PAX7, PBX1, PDGFB, PDGFRB, PHF1, PLAG1, POU5F1, RAD51B, RANBP2, ROS1, SEC31A, SRF, SS18, SSX1, SSX2, SSX4B, STAT6, SUZ12, SYK, TAF15, TCF12, TEAD1, TFE3, TFG, THRAP3, TPM3, TPM4, USP6, WT1, WWTR1, YAP1, YWHAE and ZNF444.
As of May 12, 2025, this test serves as replacement for the following test(s) that are no longer offered:
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Ewing Sarcoma NGS Fusion Panel
-
NeoTYPE® Liposarcoma Fusion Profile
-
Non-Ewing Sarcoma NGS Fusion Panel
-
Rhabdomyosarcoma NGS Fusion Panel
Specimen Requirements
FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81456
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
RNA Sequencing
| Fusions | |||||
|---|---|---|---|---|---|
| ACTB | AHRR | ALK | ASPSCR1 | ATF1 | ATIC |
| BCOR | BRAF | C11orf95 | CAMTA1 | CARS1 | CCNB3 |
| CDH11 | CIC | CLTC | CNBP | COL1A1 | COL1A2 |
| CREB1 | CREB3L1 | CREB3L2 | CSF1 | CTNNB1 | DDIT3 |
| DUX4 | EML4 | EPC1 | ERG | ETV1 | ETV4 |
| ETV6 | EWSR1 | FEV | FLI1 | FOXO1 | FRK |
| FUS | GLI1 | HAS2 | HEY1 | HMGA2 | IL2RB |
| ITK | JAZF1 | LMNA | LPP | MEAF6 | MRTFB |
| MYH9 | MYLK | NAB2 | NCOA1 | NCOA2 | NFATC2 |
| NFIB | NR4A3 | NTRK1 | NTRK2 | NTRK3 | NUTM2A |
| NUTM2B | OMD | PATZ1 | PAX3 | PAX7 | PBX1 |
| PDGFB | PDGFRB | PHF1 | PLAG1 | POU5F1 | RAD51B |
| RANBP2 | ROS1 | SEC31A | SRF | SS18 | SSX1 |
| SSX2 | SSX4B | STAT6 | SUZ12 | SYK | TAF15 |
| TCF12 | TEAD1 | TFE3 | TFG | THRAP3 | TPM3 |
| TPM4 | USP6 | WT1 | WWTR1 | YAP1 | YWHAE |
| ZNF444 | |||||
Last Updated: March 02, 2026