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MGMT Promoter Methylation Analysis
- Molecular
Bisulfite modification of tumor DNA and real-time PCR are used to quantify CpG methylation within the MGMT gene promoter. Please note detection of MGMT promoter methylation analysis is qualitative.
As of May 12, 2025, this test serves as replacement for the following test(s) that are no longer offered:
- Brain NGS Fusion Panel
Specimen Requirements
FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives. A minimum of 40% tumor is required. If the tumor cannot be enriched to at least 40%, then testing will not be performed.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
81287
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: July 28, 2025