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BCR-ABL1 Non-Standard p230
- Molecular
This test uses real-time RT-PCR for detection of t(9;22) BCR-ABL1 fusion transcripts that result in p230 (e19a2) fusion proteins. Analytical sensitivity is 0.1%. Results are reported as Detected or Not Detected.
Test Customization: Can be ordered as a reflex when BCR-ABL1 Standard p210, p190 is negative.
Clinical Significance
Subsets of patients with Ph1+ chronic myeloid leukemia (CML) have a unique breakpoint within the BCR gene on chromosome 22. This breakpoint is 3' to the more common breakpoints found in patients with CML and ALL and can lead to e19a2 fusion transcript. Thus, p230 BCR ABL1 contains additional BCR coding sequences that are not found in the p190 or p210 variants. The incidence of this translocation is very rare, but may lead to falsely negative molecular testing when the molecular testing is designed to detect breakpoints in E1, E13 or E14.
Although some studies suggested that the course of CML in patients with p230 is milder than that in average CML, response to therapy is similar. However, very little literature is available due to the rarity of this abnormality. This test is not recommended as a sole primary diagnostic test for CML or other acute leukemia.
Specimen Requirements
Bone Marrow Aspirate: 2 mL in EDTA tube.
Peripheral Blood: 5 mL in EDTA tube.
Note: Test is RNA-based. Please select Extract & Hold - RNA If specimen hold service is desired.
Note: Sodium Heparin tubes are acceptable.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. Please select Extract & Hold - RNA if specimen hold service is desired.
CPT Code(s)*
81208
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 27, 2025