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ABL1 Kinase Domain Mutation Analysis
- Molecular
This test uses RT-PCR and sequencing to detect BCR-ABL1 fusion transcript mutations associated with resistance to Gleevec (imatinib) and other tyrosine kinase inhibitors.
Includes analysis of common mutations like T315I, Y253H, E255K/V, F359V/C/I, F317L/V/I/C, T315A, and V299L.
Specimen Requirements
Bone Marrow Aspirate: 2 mL in EDTA tube.
Peripheral Blood: 5 mL in EDTA tube.
Note: Test is RNA-based. Please select Extract & Hold - RNA If specimen hold service is desired.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible. NYS clients please provide date and time of Collection. Please select Extract & Hold - RNA if specimen hold service is desired.
CPT Code(s)*
81170
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 05, 2025