The NTRK 1, 2, 3 FISH Panel provides simultaneous analysis of NTRK1, NTRK2, and NTRK3 for gene rearrangements (fusions) to identify TRK-inhibitor therapy and clinical trial options using break-apart probes.
FISH Probes:
NTRK1 (1q23.1), NTRK2 (9q21.33), NTRK3 (15q25.3)
Clinical Indications:
* Various solid tumors
NTRK 1, 2, 3 FISH Panel
- FISH
Specimen Requirements
Bone marrow aspirate: N/A
Peripheral blood: N/A
Fresh, unfixed tissue: N/A.
Fluids: N/A
Paraffin block: Send paraffin block. Also send circled H&E slide for tech-only (required).
Cut slides: H&E slide (required) plus 5 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88377x3 manual or 88374x3 automated
Turnaround time
3-5 Days
Level of Service
- Global
- Tech Only
Integrations
Request electronic integrations →
New York Approved: Yes
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
DNA Sequencing
| Fusions | |||||
|---|---|---|---|---|---|
| NTRK2 | |||||
RNA Sequencing
| Fusions | |||||
|---|---|---|---|---|---|
| NTRK1 | |||||
Fluorescence In Situ Hybridization (FISH)
| Fusions | |||||
|---|---|---|---|---|---|
| NTRK3 | |||||
Last Updated: April 29, 2026