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MDS Standard FISH Panel
- FISH
This FISH Panel was designed to detect key chromosomal abnormalities associated with myelodysplastic syndrome (MDS). It includes the following probes:
5q-, -5 (5p15, 5q31, 5q33)
7q-, -7 (Cen 7, 7q22, 7q31)
Trisomy 8 (Cen 8)
p53 (17p13.1)/NF1 (17q11)
20q- (20q12, 20qter)
RPN1, MECOM (3q21, 3q26.2)
Optional Reflex (available with Global cases only):
ETV6 (12p13)
MLL (11q23)
+19 (19p13.2, 19q13)
when the main panel is negative.
Test Customization: Probes may be ordered separately except +8 and 20q- which are combined. Reflex results will be reported separately as MDS Standard Reflex Panel.
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 4 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x5 automated. If reflex is added, add 88374x3.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 05, 2025