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Low-Grade/Small B-Cell Lymphoma FISH Panel
- FISH
This panel is designed to detect specific genetic abnormalities commonly associated with non-Hodgkin lymphoma (NHL) and related B-cell lymphomas including B-cell lymphoma, mantle cell lymphoma (MCL), follicular lymphoma, marginal zone lymphoma (MZL), and MALT lymphoma. It includes the following probes:
BCL6 (3q27)
CCND1/IgH t(11;14)
IgH/BCL2 t(14;18)
MALT1 (18q21)
Test Customization: Probes for each translocation may be ordered separately.
Clinical Significance
This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas (such as large cell anaplastic and Burkitt lymphoma) are not a diagnostic consideration. BCL6 evaluation (included in this panel) can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma.
Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is also within this category, but typically has a peripheral blood lymphocytosis and is better evaluated by the CLL FISH Panel or NeoTYPE CLL Profile.
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 4 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
Cut Slides: H&E slide (required) plus 6 unstained slides cut at 4-5 microns.
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns for single abnormalities.
Note for Tech Only clients: Please circle H&E slide.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x4 automated. Codes may differ if manual analysis is performed.Â
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 27, 2025