FGFR3/IgH t(4;14)

  • FISH
This test uses FGFR3/IgH t(4;14) probes to detect gene rearrangements associated with multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS).
Turnaround time
3-5 Days

Level of Service

  • Global
  • Technical Only
New York Approved: Yes

Clinical Significance

FGFR3/IGH translocation plays a key role in poor prognosis associated with multiple myeloma patients. Available separately or as part of the Plasma Cell Myeloma FISH panels: Plasma Cell Myeloma IgH Complex FISH Panel and Plasma Cell Myeloma Prognostic FISH Panel.

Specimen Requirements

Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 1 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns.
Note for Tech Only clients: Please circle H&E slide.

Storage and Transportation

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of Collection.

CPT Code(s)*

88374x1 automated. Codes may differ if manual analysis is performed.

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Last Updated: August 27, 2025

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.