11q Aberration in NHL

FISH

This test uses CEN 11 (11p11.1-q11), MLL (11q23), and 11qTel (11q25) probes to detect gene abnormalities associated with B-cell non-Hodgkin lymphoma.

Turnaround time

3-5 Days

Level of Service

Global
Technical Only

New York Approved: Yes

Clinical Significance

This FISH panel detects proximal gains and distal losses of chromosome 11q which are recurrent abnormalities in MYC-negative high grade B-cell lymphomas resembling Burkitt lymphoma. "Burkitt-like lymphoma with 11q aberration" was recognized by the WHO in 2017 as a new provisional entity. This pattern of 11q abnormalities is also observed in MYC-positive Burkitt lymphomas and MYC-positive high-grade B-cell lymphomas, not otherwise specified.

Specimen Requirements

H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 3 unstained slides cut at 4-5 microns.
Note for Tech Only clients: Please circle H&E slide.

Storage and Transportation

Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.

CPT Code(s)*

88374x1 automated or 88377x1 manual

*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.

Last Updated: August 27, 2025

Get in touch

Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.