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CLL FISH Panel
- FISH
Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are tested together, and ATM is tested with p53).
Disease(s): Chronic lymphocytic leukemia
Note: This test was previously called CLL FISH Panel (non-New York). It is now New York state-approved and available to all clients.
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. Fresh, Unfixed Tissue: Tissue in RPMI. Bone Marrow/ Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: minimum 4 slides labeled with specimen type. Fluids: Equal parts RPMI to specimen volume Fixed Cell Suspension: A client fixed cell suspension may be submitted for testing as long as it is received in 3:1 Methanol:Glacial Acetic Acid. Paraffin Block: Send paraffin block. Also send circled H&E slide for tech-only (required). Note: Not approved for NYS samples. Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only. Note: Not approved for NYS samples. Note: Please exclude biopsy needles, blades, and other foreign objects from transport tubes. These can compromise specimen viability and yield, and create hazards for employees.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x4 automated. Codes may differ if manual analysis is performed.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: January 22, 2025