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Probes: CBFB inv(16), t(6;16) | KMT2A (MLL) (11q23) | PML/RARA t(15;17) | RUNX1/RUNX1T1 (ETO/AML1) t(8;21) | RPN1, MECOM (3q21, 3q26.2)
Optional Reflex (available with Global cases only): 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | DEK/NUP214 (CAN) t(6;9) | p53 (17p13.1)/NF1 (17q11) | NUP98 (11p15) when the main panel is negative.
Probes may be ordered separately. Reflex results will be reported separately as AML Standard Reflex Panel.
Disease(s): Acute myeloid leukemia
Note: STAT processing is available by request for PML-RARA. Note STAT along with MD contact name and phone number to receive STAT results.
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 7 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
88374x5 automated. If reflex is added, add 88374x5.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: July 28, 2025