Get in touch
Our Client Services team is on hand to help. Please call us at 866.776.5907, Option 3.
AML Standard FISH Panel
- FISH
This panel is designed for the detection of genetic abnormalities commonly associated with acute myeloid leukemia (AML). It includes the following probes:
CBFB inv(16), t(6;16)
KMT2A (MLL) (11q23)
PML/RARA t(15;17)
RUNX1/RUNX1T1 (ETO/AML1) t(8;21)
RPN1, MECOM (3q21, 3q26.2)
Optional Reflex (available with Global cases only):
5q-, -5 (5p15, 5q31, 5q33)
7q-, -7 (Cen 7, 7q22, 7q31)
DEK/NUP214 (CAN) t(6;9)
p53 (17p13.1)/NF1 (17q11)
NUP98 (11p15) when the main panel is negative.
Test Customization: Probes may be ordered separately. Results will be reported separately as AML Standard Reflex Panel.
STAT Processing (upon request): Available for PML/RARA t(15;17). Include "STAT" along with the requesting physician's name and contact information for expedited results.
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 7 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x5 automated. If reflex is added, add 88374x5.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 05, 2025