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AML Non-Favorable Risk Panel
- FISH
This FISH Panel is designed to detect common cytogenetic abnormalities associated with acute myeloid leukemia (AML), which can provide valuable prognostic information. This panel includes the following probes:
RPN1, MECOM (3q21, 3q26.2)
5q-, -5 (5p15, 5q31, 5q33)
7q-, -7 (Cen 7, 7q22, 7q31)
Trisomy 8 (Cen 8)
DEK/NUP214 (CAN) t(6;9)
MLL (11q23)
ETV6 (12p13)
17p- (TP53 17p13.1, NF1 17q11.2)
Test Customization: Probes may be ordered separately.
Clinical Significance
The AML Non-Favorable Risk FISH Panel accommodates US and international cytogenetic risk classifications for intermediate and adverse risk groups. This Panel was formerly called AML Extended Panel.
Specimen Requirements
Bone Marrow Aspirate: 1-2 mL in sodium heparin tube. EDTA tube is acceptable.
Peripheral Blood: 2-5 mL in sodium heparin tube. EDTA tube is acceptable.
Fresh, Unfixed Tissue: Tissue in RPMI.
Bone Marrow/Peripheral Blood Smear or Fresh Tissue Touch Preparation Slides: Minimum 8 slides, labeled with specimen type.
Fluids: Mix in equal parts with RPMI (specimen volume to RPMI ratio of 1:1).
Fixed Cell Suspension: A client-prepared fixed cell suspension is acceptable if received in 3:1 Methanol:Glacial Acetic Acid.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x8 automated. Codes may differ if manual analysis is performed.
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 27, 2025