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Anaplastic Large Cell Lymphoma FISH Panel
- FISH
This panel is designed to detect key genetic abnormalities associated with anaplastic large cell lymphoma (ALCL) and peripheral T-cell lymphoma (PTCL). It includes the following probes:
ALK (2p23)
TP63 (3q28)
TBL1XR1/TP63 [inv(3)(q26q28)]
DUSP22-IRF4 (6p25.3)
Testing Scheme: TP63 (3q28) and TBL1XR1/TP63 [inv(3)(q26q28)] are performed together and reported as co-dependent for the result and interpretation of TP63 rearrangement status.
Test Customization: Tech Only clients may order probes individually.
Specimen Requirements
H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 6 unstained slides cut at 4-5 microns.
Note for Tech Only clients: Please circle H&E slide.
Storage and Transportation
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88374x4 automated or 88377x4 manual
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: August 05, 2025