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Ploidy FISH for Molar Pregnancy
- FISH
Ploidy FISH analyzes centromeres 1 and 11 to assess triploidy (associated with partial mole) vs. diploidy (associated with complete mole).
Probes: Centromere 1 (1p11.1-q11.1) | Centromere 11 (11q12)
Antibody Marker: p57
Disease(s): Complete molar pregnancy vs. partial mole vs. abortus with hydropic changes
This test is available on a consult basis only.
Specimen Requirements
Bone Marrow Aspirate: N/A
Peripheral Blood: N/A
Fresh, Unfixed Tissue: N/A
Paraffin Block: H&E slide (required) plus paraffin block.
Cut Slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns.
Note: Specimen must contain villi and/or fetal tissue.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88377x1 manual or 88374x1 automated
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Biomarkers
Fluorescence In Situ Hybridization (FISH)
| Polyploidy | |||||
|---|---|---|---|---|---|
| Centromere 11 | Centromere 1 | ||||
Last Updated: February 05, 2026