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Congo Red
- Immunohistochemistry (IHC)
Special stain. Amyloidosis is a rare disease characterized by the deposition of insoluble misfolded proteins in various tissues and organs. Congo red stain is the gold standard for the demonstration of amyloid in tissue sections. The amyloid fibril Congo red complex demonstrates 'apple green' birefringence using polarized light microscopy. For cases with positive Congo red staining, immunohistochemical stains for amyloid A, amyloid P and immunoglobulin light chains are available for further evaluation of the amyloid subtype, if clinically indicated.
Specimen Requirements
A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or one (1) unbaked, unstained slide cut at 4-5 microns for H&E staining (required) and two to three (2-3) positively charged unstained slides cut at 10 microns.
Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
NOTE: Clients should perform manual evaluation of the glass slide with polarized light for complete evaluation. Scanning at NeoGenomics is done with routine light microscopy.
Storage and Transportation
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. NYS clients please provide date and time of Collection.
CPT Code(s)*
88313 x1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: July 28, 2025