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Pan-TRK (clone EPR17341) is directed against the C-terminal region of TRK (tropomyosin receptor kinase) A, B, and C proteins, which are encoded by NTRK1, NTRK2, and NTRK3 genes respectively. Pan-TRK IHC staining is a useful screen for identification of NTRK protein overexpression caused by gene fusions. Correlation of IHC staining with molecular detection of TRK fusions is moderate; discrepant cases have been described. IHC screening is not recommended in neuroendocrine tumors, GISTs, gliomas, or adult sarcomas, as these tissues show positive staining in the absence of an NTRK translocation. Published sensitivity rates of IHC staining for detection of NTRK fusions (detected by molecular testing) are 95% and above. Follow-up molecular testing is available to confirm positivity and identify the specific NTRK gene rearranged and its fusion partner gene.
88342 x 1 or 88341 x 1
*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
Last Updated: July 28, 2025