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S100 belongs to the family of calcium binding proteins. Antibody to S100 stains Schwannomas, ependymomas, astrogliomas, almost all benign melanocytic lesions, melanomas and their metastases. S100 protein is also expressed in the Langerhans cells in…
Immunohistochemistry (IHC)
Expression of S100P, a member of the S100 family, is increased in a number of tumors, including pancreas, lung, breast, and ovary carcinomas. S100P can be seen in many pancreatic ductal carcinoma, and it displays no staining in the benign pancreatic…
Immunohistochemistry (IHC)
SALL4, a newly identified zinc-finger transcriptional factor, is required for the maintenance of embryonic stem cell pluripotency by modulating OCT4. SALL4 is a novel sensitive and highly specific marker for metastatic germ cell tumors, and is…
Immunohistochemistry (IHC)
SATB2 stains colonic and osteogenic cells and their neoplasms.
Immunohistochemistry (IHC)
Serotonin is synthesized in serotonergic neurons in the central nervous system and enterochromaffin cells in the gastrointestinal tract and serotonin-containing carcinoid tumors. Serotonin may be a useful tool for characterization of carcinoids.
Immunohistochemistry (IHC)
Available as global and tech-only. This add-on panel is available to clarify findings on samples currently having flow cytometry analysis at NeoGenomics and is not available for stand-alone testing. Markers are CD3, CD4, CD5, CD7, CD8, CD19, CD26,…
Flow Cytometry
SF1 is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF1 is highly valuable marker to determine adrenocortical origin.
Immunohistochemistry (IHC)
SF3B1 mutation analysis is performed by next-generation sequencing of all coding exons of the SF3B1 gene.
Molecular
Simian Virus 40 (SV40) is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the tumor-suppressing p53 in humans. A mutated p53…
Immunohistochemistry (IHC)
Smooth muscle actin antibody binds to smooth muscle cells and myoepithelial cells. It stains the muscularis propria and muscularis mucosae of the gastrointestinal tract, the uterine myometrium, medial layer of blood vessels, myoepithelial cells of…
Immunohistochemistry (IHC)
Smooth Muscle Myosin, Heavy Chain (SMMS-1) is an antibody to smooth muscle myosin, heavy chain that reacts with human visceral and vascular smooth muscle cells. The antibody also reacts with human myoepithelial cells. It is very helpful in…
Immunohistochemistry (IHC)
Smoothelin is a novel cytoskeletal protein that reacts with the 59 kDa and 100 kDa proteins corresponding to Smoothelin A and B, respectively, which are exclusively found in smooth muscle cells (SMC). Cells with SMC-like characteristics, such as…
Immunohistochemistry (IHC)
Somatostatin is a useful marker of D-cells of pancreatic islet cells. D-cells are used to identify hyperplasia of the pancreatic islets. Most of these tumors are malignant, giving rise to somatostatinomas. Somatostatin suppresses gastric acid…
Immunohistochemistry (IHC)
Somatostatin receptor type 2 (sstr2) is a receptor for somatostatins-14 and -28. This antibody has a great value in the assessment of sst2A status in human neuroendocrine tumors. Overexpression of somatostatin receptor 2 (Sst2r) in neuroendocrine…
Immunohistochemistry (IHC)
SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is also a useful marker in detecting both the in situ and invasive components of desmoplastic melanoma. SOX10 is diffusely expressed in…
Immunohistochemistry (IHC)
Nuclear protein expression of SOX-11 is highly associated with both cyclin D1-positive and negative mantle cell lymphoma (MCL). SOX-11 IHC is useful for identifying true cyclin D1-negative MCL and further defining pathologic features of CD5+ DLBCL.…
Immunohistochemistry (IHC)
SOX2 stains all embryonal carcinomas and is highly specific for squamous cell carcinoma.
Immunohistochemistry (IHC)
Spirochete (Treponema pallidum) is the causative agent of syphilis. In the past, localization of the spirochete agent was achieved with silver stains such as Steiners and/or Warthin-Starry. Treponema pallidum can now be successfully localized with…
Immunohistochemistry (IHC)
SRSF2 mutation analysis is performed by next-generation sequencing of all coding exons of the SRSF2 gene.
Molecular
Probes: SS18 (SYT) (18q11.2) Disease(s): Synovial sarcoma
FISH
Available as global and tech-only. Markers are CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD16, CD19, CD20, CD23, CD33, CD34, CD38, CD45, CD56, CD64, CD117, HLA-DR, kappa, and lambda.
Flow Cytometry
STAT3 mutation analysis is performed by next-generation sequencing of all coding exons of the STAT3 gene.
Molecular
STAT6 is a highly sensitive and specific immunohistochemical marker for solitary fibrous tumor (SFT) and can be helpful to distinguish this tumor type from histologic mimics.
Immunohistochemistry (IHC)
Pulmonary surfactant apoproteins play essential roles in keeping alveoli from collapsing at the end of expiration. SP-A is located mainly in type II pneumocytes and has been demonstrated in bronchiolo-alveolar carcinomas and adenocarcinomas of the…
Immunohistochemistry (IHC)
Antibody to synaptophysin reacts with neuroendocrine neoplasms of neural as well as epithelial types. In combination with chromogranin A and NSE antibodies, the antibody to synaptophysin is very useful in the identification of normal neuroendocrine…
Immunohistochemistry (IHC)