NeoGenomics Laboratories
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Methodology
Test Name
Test Description
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FISH
13q-/-13
Component(s) / Chromosome(s)
: 13
Gene(s)
: D13S319, LAMP1
Disease State
: B-cell chronic lymphocytic leukemia (B-CLL), Multiple Myeloma
View
FISH
20q-
Component(s) / Chromosome(s)
: 20
Gene(s)
: D20S108
Disease State
: Myelodysplasia (MDS)
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FISH
5q-/-5
Component(s) / Chromosome(s)
: 5
Gene(s)
: D5S721-D5S23, CSF1R
Disease State
: Myelodysplasia (MDS)
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FISH
7q-/-7
Component(s) / Chromosome(s)
: 7
Gene(s)
: CEN7, D7S486
Disease State
: Myelodysplasia (MDS)
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FISH
8
Component(s) / Chromosome(s)
: 8
Gene(s)
: CEN8
Disease State
: B-ALL, Non-Hodgkin's Lymphoma (NHL)
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IHC
AFB
Special stain. Ziehl-Neelsen Acid-Fast Bacteria Stain is used to detect the presence of acid-fast mycobacteria in tissue sections. Acid-fast techniques are of value in the detection of mycobacteria, rod-shaped organisms that sometimes exhibit filamentous (fungus-like) growth. The most significant disease-producing mycobacteria are Mycobacterium tuberculosis and Mycobacterium leprae.
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IHC
AFP
AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
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FISH
ALK (2p23)
Component(s) / Chromosome(s)
: 2
Gene(s)
: ALK
Disease State
: Anaplastic Large Cell Lymphoma, Non-Hodgkin's Lymphoma (NHL), Lymphoma, Non-Small Cell Lung Carcinoma (NSCLC)
Get the full details on ALK FISH
.
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IHC
ALK1
Recognizes a human p80 protein, identified as a hybrid of the anaplastic lymphoma kinase (ALK) gene and the nucleophosmin (NPM) gene resulting from the t(2;5)(p23;q35) translocation found in 30-50% of CD30+ large cell lymphomas (1). This rabbit monoclonal antibody can be used to detect p80 in these lymphomas and may also be used to detect a recently described subtype of large B cell lymphoma, which expresses the full-length ALK protein (2).
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FISH
AML Panel
Component(s) / Chromosome(s)
: 5, 7, 8, 11, 15, 16, 17, 21
Gene(s)
: D5S721-D5S23, CSF1R, CEN7, D7S486, CEN8, MLL, ETO, AML1, PML, RARA, CBFB
Disease State
: Acute Myeloid Leukemia
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