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Methodology Test Name Test Description Results per page:
IHC Acute Leukemia IHC Panel

Staining with the following antibodies to identify acute leukemia in bone marrow clots and core biopsies: CD3, CD7, CD20, CD34, CD45 LCA, CD56, CD117, MPO, PAX-5, and TdT.

This panel is available on a tech-only basis. For global testing, please order a consult so our pathologists may select the best combination of stains for your case. 

IHC Adenocarcinoma vs. Mesothelioma IHC Panel Staining with the following seven antibodies to differentiate pulmonary adenocarcinoma from malignant mesothelioma, epithelial type: Pan-Cytokeratin Plus, CEA, MOC-31, BerEP4, TTF1, calretinin, and WT-1.

This panel is available on a tech-only basis. For global testing, please order a consult so our pathologists may select the best combination of stains for your case.

FISH ALL Adult FISH Panel
  • Disease(s):  Acute lymphoblastic (lymphocytic) leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), adult
  • Probes:  
    • TCF3/PBX1 (E2A/PBX1) t(1;19)
    • Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17)
    • MYC (8q24)
    • BCR/ABL1/ASS1 t(9;22) 
    • MLL (11q23)
    • IgH (14q32)
    • Probes may be ordered separately except Centromeres 4 and 17 are paired, and Centromeres 6 and 10 are paired. 

 

FISH ALL Pediatric FISH Panel
  • Disease(s): Acute lymphoblastic (lymphocytic) leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), pediatric
  • Probes:  
    • TCF3/PBX1 (E2A/PBX1) t(1;19)
    • Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17)
    • MYC (8q24)
    • BCR/ABL1/ASS1 t(9;22) 
    • MLL (11q23)
    • ETV6/RUNX1 (TEL/AML1) t(12;21)
    • IgH (14q32)
    • Probes may be ordered separately except Centromeres 4 and 17 are paired, and Centromeres 6 and 10 are paired. 
FISH AML Favorable-Risk Panel
  • Disease(s):
    • Acute myeloid leukemia
  • Probes:
    • RUNX1/RUNX1T1 (ETO/AML1) t(8;21)
    • PML/RARA t(15;17)
    • CBFB inv(16), t(16;16)
    • Probes may be ordered separately.
FISH AML Non-Favorable Risk Panel (non-NY)

Note: This panel was previously named AML Extended Panel.

  • Disease(s):
    • Acute myeloid leukemia
  • Probes:
    • RPN1, MECOM (3q21, 3q26.2)
    • 5q-, -5 (5p15, 5q31, 5q33)
    • 7q-, -7 (7q31, Cen 7)
    • Trisomy 8 (Cen 8)
    • DEK/CAN t(6;9)
    • MLL (11q23)
    • ETV6 (12p13)
    • 17p- (TP53 17p13.1, Cen 17 dual-color)
    • Probes may be ordered separately.
FISH AML Standard Panel (non-New York)
  • Disease(s):  Acute myeloid leukemia
  • Probes
    • 5q-, -5  (5p15, 5q31, 5q33)
    • 7q-, -7  (7q31, Cen 7) 
    • Trisomy 8  (Cen 8) 
    • MLL (11q23)
    • 20q- (20q12, 20qter)
    • RUNX1/RUNX1T1 (ETO/AML1) t(8;21) 
    • PML/RARA t(15;17) 
    • CBFB inv(16), t(16;16)
    • Probes may be ordered separately except +8 and 20q- which are combined.  
IHC B-Cell Lymphoma Panel Staining with the following 12 antibodies for diagnosis, grading, and determining the prognosis of various subtypes of B-cell lymphoma: BCL-1, BCL-2, BCL-6, CD3, CD5, CD10, CD20, CD23, CD30, Ki-67, MUM1, PAX-5.

This panel is available on a tech-only basis. For global testing, please order a consult so our pathologists may select the best combination of stains for your case.

FISH Bladder Cancer
  • Disease(s): Bladder cancer
  • Probes:
    • +3 (Cen 3)
    • +7 (Cen 7)
    • p16 (9p21)
    • +17 (Cen 17)
IHC Burkitt vs. DLBC Lymphoma IHC Panel Staining with the following antibodies to distinguish Burkitt, DLBCL, and double-hit lymphoma: BCL-2, c-MYC, Ki-67. FISH testing for MYC rearrangements may be useful in the work-up of this differential diagnosis.

This panel is available on a tech-only basis. For global testing, please order a consult so our pathologists may select the best combination of stains for your case.

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