MelanoSITE™: Genetic Analysis for Ambiguous Melanocytic Lesions

MelanoSITE is a four-probe FISH assay that enhances diagnostic discrimination between nevi and melanoma. FISH analysis enables rapid, cost-effective insight into genetic abnormalities that characterize progression to malignancy in many lesions.

Using a published algorithm that focuses on four chromosome regions most predictive of malignancy¹ and internally validated cut-offs, MelanoSITE provides 84% sensitivity and 98% specificity in identification of melanoma.²  This molecular technique expands on traditional histologic evaluation and serves as a useful adjunct in resolution of ambiguous cases.³

Dermatopathologists choose the level of service:

• Comprehensive Consult: MelanoSITE testing is performed at NeoGenomics.  Results are interpreted and reported by a nationally-recognized dermatopathology expert in the context of clinical history and related test results.  IHC and special staining may be done if medically necessary.
• Global Option: Testing is performed at NeoGenomics.  Interpretation and report of the MelanoSITE result is performed by NeoGenomics’ board-certified dermatopathologists.
• Tech-Only Option: The testing technical component is performed at NeoGenomics, with images and raw data delivered back to our clients via a secure web-based portal for their interpretation.  This allows our clients control of the final diagnosis and creates revenue opportunity for them through professional component billing.  Training, custom report templates, and vacation coverage are available.

Download printable specimen requirements, levels of service, and a sample report.

Read more about “FISH as an Effective Diagnostic Tool for the Management of Challenging Melanocytic Lesions" in this 2011 reference article.

Contact us to request more information.

MelanoSITE Probes

MelanoSITE by FISH reveals the number of four chromosome regions significant in melanoma. A normal cell has two copies of each region targeted by red, green, yellow, or aqua-colored probes. Loci detected by each color probe are shown on the right.

Case Studies

Noted dermatopathologist Dr. Artur Zembowicz incorporates MelanoSITE into evaluation of atypical nevi, Spitz tumors, and other melanocytic proliferations. Comprehensive consultations by Dr. Zembowicz with MelanoSITE can be requested through NeoGenomics. Please contact us at customercare@neogenomics.com or 866.776.8907.

Over 100 studies from his practice are available for your review. 
View Dr. Zembowicz's Case Studies

References

1. Gerami P et al. Am J Surg Pathol. 2009;33:1146-1156.
2. Moore M, Gasparini R. Diagnostic Pathology. 2011;6:76+.
3. Gerami P, Zembowicz A. Arch Pathol Lab Med. 2011;135:830-837.

MelanoSITE is a registered trademark of NeoGenomics Laboratories, Inc.