Colorectal Cancer Testing
Comprehensive and flexible options
|Test Name||Description||Specimen Requirements||TAT (days)||Ordering Options|
|MMR IHC||Staining with antibodies to MLH1, MSH2, MSH6, and PMS2 to identify mismatch repair defect. Stains are run concurrently.||Cut slides or FFPE tumor block: details for IHC||2||Full IHC consult, global with interpretation, Tech-Only IHC|
|MSI by PCR||PCR-based comparison of tumor and non-tumor DNA to detect microsatellite instability at the five NCI-recommended loci.||H&E slide, cut tumor slides or FFPE tumor block, and source of non-tumor patient DNA: details for MSI
|KRAS w/reflex to BRAF||
Sequencing to detect KRAS mutations in codons 12, 13, and 61. If negative, BRAF sequencing for V600 and other mutations is added automatically.
|H&E slide plus cut slides or FFPE tumor block: details for KRAS/BRAF||7||Tech-Only|
Notes: Individual IHC stains are available by request.
|Colorectal Cancer Panel||Any two or three of the above tests on the same patient sample.||For multiple tests, please send H&E slide plus FFPE tumor block instead of cut slides for testing.
Follow MSI detailed requirements if ordering that test in a panel.
|7||Clients participating in tech-only can bill one IHC professional component (PC) per antibody per patient sample tested.|
Please use the Green/Gray NeoGenomics Solid Tumor Requisition and check all desired tests in the FISH and Solid Tumor Panels section near the bottom.